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研究業績 教授就任前（～2002年）

著書

  1. 池田慎一郎、三高俊広. 肝前駆細胞からの増殖と分化：小型肝細胞（small hepatocyte）の分離法．５章：171-178、幹細胞・クローン研究プロトコール、中辻憲夫編、羊土社、東京、2001．
  2. Mitaka T, Sato F. “Chapter 14: Small Hepatocytes in Primary Cultures” Berry M and Edwards AM, eds. In The Hepatocyte Review, Kluwer academic publishers, Dordrecht, pp. 195-208, 2000.
  3. 望月洋一、三高俊広. 肝臓　日本電子顕微鏡学会編。電子顕微鏡でみるミクロの世界.　208-209．学際企画、東京、1995.

総説・原著論文

  1. Mitaka T*. Reconstruction of hepatic organoid by hepatic stem cells. J Hepatobiliary Pancreat Surg, 9(6), 697-703 (2002)
  2. Sugimoto S, Mitaka T*, Ikeda S, Harada K, Ikai I, Yamaoka Y, Mochizuki Y. Morphological changes induced by extracellular matrix are correlated with maturation of rat small hepatocytes. J Cell Biochem, 87(1), 16-28 (2002)
  3. Ikeda S, Mitaka T*, Sugimoto S, Harada K, Mochizuki Y. Proliferation of rat small hepatocytes after long-term cryopreservation. J Hepatol, 37(1), 7-14 (2002)
  4. Katsura N, Ikai I*, Mitaka T, Shiotani T, Matsushita T, Yamanokuchi S, Sugimoto S, Kanazawa A, Terajima H, Mochizuki Y, Yamaoka Y. Long-Term Culture of Primary Human Hepatocytes with Preservation of Proliferative Capacity and Differentiated Functions. J Surg Res, 106(1), 115-123 (2002)
  5. Mizuguchi T, Palm K, Hui T, Aoki T, Mochizuki Y, Mitaka T, Demetriou AA, Rozga J*. Effects of bone marrow stromal cells on the structural and functional polarity of primary rat heptocytes. In Vitro Cell Dev Biol, 38(2), 62-65 (2002).
  6. Takagi C, Ueki K, Ikeuchi H, Kuroiwa T, Kaneko Y, Tsukada Y, Maezawa A, Mitaka T, Sasaki T, Nojima Y*. Increased Expression of Cell Adhesion kinase b in Human and Rat Crescentic Glomerulonephritis. Am J Kid Dis 39(1), 174-182 (2002)
  7. Manase K, Endo T*, Henmi H, Hayashi T, Kitajima Y, Nishikawa A, Mitaka T, Sato H, Kudo R. The significance of membrane type 1 metalloproteinase in structural involution of human corpora lutea. Mol Hum Reprod, 8(8), 742-749 (2002)
  8. 三高俊広.　動き出した再生医療の臨床　～肝臓～.　分子細胞治療　1(1): 78-85 (2002)
  9. Mitaka T*, Sato F, IkedaS, Sugimoto S, Higaki N, Hirata K, Lamers WH, Mochizuki Y. Expression of carbamoylphosphate synthetase I and glutamine synthetase in hepatic organoids reconstructed by rat small hepatocytes and hepatic nonparenchymal cells. Cell Tissue Res, 306, 467-471 (2001)
  10. Mizuguchi T, Hui T, Palm K, Sugiyama N, Mitaka T, Demetriou AA, Rozga J*. Enhanced proliferation and differentiation of rat hepatocytes cultured with bone marrow stromal cells. J Cell Physiol, 189(1), 106-119 (2001)
  11. Yanai Y, Furuhata T*, Kimura Y, Yamaguchi K, Yasoshima T, Mitaka T, Mochizuki Y, and Hirata K. Vascular endothelial growth factor C promotes human gastric carcinoma lymph node metastasis in mice. J Exp Clin Cancer Res, 20(3), 419-428 (2001)
  12. Mizuguchi T, Kamohara Y, Hui T, Neuman T, Mitaka T, Demetriou AA, Rozga J*. Regulation of c-met expression in rats with acute hepatic failure. J Surg Res, 99(2), 385-396 (2001)
  13. Higaki N, Mitaka T*, Sato F, Hirata K, Mochizuki Y. Maintenance of connexin 32 and 26 expression in primary cultured rat hepatocytes treated with 3-acetylpyridine. J Gastroenterol Hepatol, 16(7), 806-815 (2001)
  14. Hirata K*, Ikeda S, Honma T, Mitaka T, Furuhata T, Katsuramaki T, Hata F, Mukaiya M. Sepsis and cholestasis: basic findings in the sinusoid and bile canaliculus. J Hepatobiliary Pancreat Surg, 8(1): 20-26 (2001).
  15. Mitaka T*. Hepatic Stem Cells: From Bone Marrow Cells to Hepatocytes. Biochem Biophys Res Commun, 281(1), 1-5 (2001)
  16. 三高俊広、池田慎一郎、杉本真一.　肝臓の再生.　肝胆膵、42(2), 195-201（2001）
  17. 三高俊広.　肝臓の幹細胞.　Molecular Medicine, 38(1), 8-15 (2001)
  18. 三高俊広、原田　敬介、池田慎一郎、杉本真一。肝臓の幹細胞システム。GI Research, 19(3), 229-234 (2001)
  19. Aoto H, Mitaka T, Sasaki H, Ishino M, Mochizuki Y, Sasaki T*. Association of cell adhesion kinase β (CAKβ/PYK2) with cytoskeleton. Tumor Res, 35, 35-47 (2000)
  20. Mizuguchi T, Mitaka T*, Sato F, Mochizuki Y, Hirata K. Paper is compatible bed for rat hepatocytes. Artif Organs, 24(4), 271-277 (2000).
  21. 三高俊広.　肝臓における幹細胞システムと肝組織再構築.　実験医学、18 (4) Mar, 431-437 (2000)
  22. Sato F, Mitaka T*, Mizuguchi T, Mochizuki Y, Hirata K. Effects of nicotinamide-related agents on the growth of primary rat hepatocytes and formation of small hepatocyte colonies. Liver, 19(6), 481-488 (1999).
  23. Minamitsuji-Mochizuki C, Mitaka T, Kojima T, Niitsu Y, Mochizuki Y*. Spontaneous appearance of circular actin bands in cultured hepatocytes of adult rats. Med Electron Microsc, 32(1), 114-121 (1999)
  24. Atsumi S, Kokai Y*, Tobioka H, Kuwahara K, Kuwabara H, Takakuwa Y, Sasaki K, Sawada N, Mitaka T, Mochizuki Y, Imai K, Mori M. Occludin modulates organization of peri-junctional circumferential actin in rat endothelial cells. Med Electron Microsc, 32(1), 11-19 (1999)
  25. Naishiro Y, Adachi M*, Okuda H, Yawata A, Mitaka T, Takayama S, Reed JC, Hinoda Y, Imai K. BAG-1 accelerates cell motility of human gastric cancer cells. Oncogene, 18(21), 3244-3251 (1999).
  26. Mitaka T*, Sato F, Mizuguchi T, Yokono T, Mochizuki Y. Reconstruction of Hepatic Organoid by Small Hepatocytes and Hepatic Nonparenchymal cells. Hepatology, 29(1), 111-125 (1999).
  27. 池田慎一郎、三高俊広、平田公一.　肝再生と肝幹細胞-臨床応用へ向けて-　Surgery Frontier, 6 (3), 314-317 (1999)
  28. 三高俊広、佐藤文彦.　肝ステムセルの分化と増殖　I.　組織培養工学、25 (2) Feb, 57-61（1999）
  29. Kojima T*, Sawada N, Takakuwa Y, Takakuwa R, Mitaka T, Mori M, Mochizuki Y. Effects of the Protein Phosphatase Inhibitors, Okadaic Acid and Vanadate, on Localization of Occludin in primary Cultures of Rat Hepatocytes. Tumor Res, 33,15-26 (1998)
  30. Mizuguchi T, Mitaka T*, Hirata K, Mochizuki Y. Alteration of Expression of Liver-Enriched Transcription Factors in the Transition between Growth and Differentiation of Primary Cultured Rat Hepatocytes. J Cell Physiol, 174 (3), 273-284 (1998)
  31. Matsuya M, Sasaki H, Aoto H, Mitaka T, Nagura K, Ohba T, Ishino M, Takahashi S, Suzuki R, Sasaki T*. Cell Adhesion Kinase β (CAKβ) Forms a Complex with a New Member, Hic-5, of Proteins Localized at Focal Adhesions. J Biol Chem, 273 (2), 1003-1014 (1998)
  32. Mitaka T. The current status of primary hepatocyte culture. Internat J Exp Pathol, 79, 393-409 (1998)
  33. Mitaka T, Sato F, Mizuguchi T, Mochizuki C, Mochizuki Y. Growth and Differentiation of Small Hepatocytes. J Gastroenterol Hepatol, 13 (SUPPL.), S70-77 (1998)
  34. 三高俊広、小島隆、水口徹.　肝の再生：初代培養肝細胞研究から肝再生現象を考えるBIO clinica , 13(6), 465-469 (1998)
  35. Kojima T*, Yamamoto M, Mochizuki C, Mitaka T, Sawada N, Mochizuki Y. Different changes in expression and junction of connexin 26 and connexin 32 during DNA synthesis and redifferentiation in primary rat hepatocytes using a DMSO culture system. Hepatology, 26 (3), 585-597 (1997)
  36. Kojima T*, Mochizuki C, Mitaka T, Mochizuki Y. Effects of melatonin on proliferation, oxidative stress and Cx32 gap junction protein expression in primary cultures of adult rat hepatocytes. Cell Struct Funct, 22 (3), 347-356 (1997)
  37. Kojima T*, Mochizuki C, Tobioka H, Saitoh M, Takahashi S, Mitaka T, Mochizuki Y. Formation of actin filament networks in cultured rat hepatocytes treated with DMSO and glucagon. Cell Struct Funct, 22(2), 269-278 (1997)
  38. Mitaka T*, Shindoh M, Mochizuki Y, Sasaki H, Ishino M, Matsuya M, Ninomiya T, Sasaki T. Restricted Expression of Cell Adhesion Kinase-beta in Rat Tissues. Am J Pathol, 150(1), No.1; 267-281 (1997)
  39. 佐藤文彦、水口徹*、伝野隆一、平田公一、三高俊広、望月洋一.　ヒト胃癌由来細胞株とその肝高転移株における細胞外カルシウム濃度と細胞運動能の検討.　消化器癌の発生と進展、9, 361-362（1997）
  40. 三高　俊広. 肝臓の多能性幹細胞.　Molecular Medicine, 34(5), 554-565 (1997)
  41. 水口徹*、平田公一、三高俊広.　スーパー肝細胞.　Surgery Frontier, 4(1), 61-65 (1997).
  42. Mizuguchi T, Mitaka T*, Kojima T, Hirata K, Mochizuki Y. Recovery of mRNA Expression of Tryptophan 2,3-Oxygenase and Serine Dehydratase in the Long-term Cultures of Primary Rat Hepatocytes. J Biochem, 120(3), 511-517 (1996)
  43. Mitaka T*, Kojima T, Mizuguchi T, Mochizuki Y. Subculture of proliferating primary adult rat hepatocytes in medium supplemented with nicotinamide and EGF. In Vitro Cell Dev Biol Animal, 32(8), 469-477 (1996)
  44. Kojima T*, Yamamoto M, Tobioka H, Mizuguchi T, Mitaka T, Mochizuki Y. Changes in cellular distribution of connexins 32 and 26 during formation of gap junctions in primary cultures of rat hepatocytes. Exp Cell Res, 223(2), 314-326 (1996)
  45. Kojima T*, Mitaka T, Mizuguchi T, Mochizuki Y. Effects of oxygen radical scavengers on connexin 26 and 32 expression in primary cultures of adult rat hepatocytes. Carcinogenesis, 17(3), 537-544 (1996)
  46. Kaya M, Yoshida K, Higashino F, Mitaka T, Ishii S, Fujinaga K*. A single ets-related transcription factor E1AF confers invasive phenotype on human cancer cells. Oncogene, 12(12), 221-227 (1996)
  47. Norioka K*, Mitaka T, Kojima T, Mochizuki Y. Tumor necrosis factor-induced endothelial cell injury with advancing age in vitro. In Vitro Cell Dev Biol, 31(11), 824-827 (1995)
  48. Mitaka T*, Kojima T, Mizuguchi T, Mochizuki Y. Growth and Maturation of Small Hepatocytes Isolated from Adult Rat Livers. Biochem Biophys Res Commun, 214(2), 310-317 (1995)
  49. Kojima T*, Mitaka T, Shibata Y, Mochizuki Y. Induction and Regulation of Connexin 26 by Glucagon in Primary Cultures of Adult Rat Hepatocytes. J Cell Sci, 108(8), 2771-2780 (1995)
  50. Mitaka T*, Kojima T, Norioka K, Mochizuki Y. TGF-β Completely Blocks the Formation of Small-Cell Colonies: Effects of Mito-inhibitory Factors on the Proliferation of Primary Cultured Rat Hepatocytes. Cell Struct Funct, 20(2), 167-176 (1995).
  51. Norioka N*, Mitaka T, Kojima T, Mochizuki Y. Effects of Aurintricarboxylic Acid on the Apoptosis and the Growth of Human Vascular Endothelial Cells. In Vitro Cell Dev Biol, 31(5), 323-325 (1995).
  52. Kojima T*, Mitaka T, Paul DL, Mori M, Mochizuki Y. Reappearance and Long-term Maintenance of Connexin 32 in Proliferated Adult Rat Hepatocytes: Use of Serum-free L-15 Medium Supplemented with EGF and DMSO. J Cell Sci, 108(4), 1347-1357 (1995)
  53. Norioka K*, Mitaka T, Mochizuki Y, Hara M, Kawagoe M, Nakamura H. Interaction of interleukin-1 and interferon-α on fibroblast growth factor-induced angiogenesis. Jpn J Cancer Res, 85(5), 522-529 (1994)
  54. Mitaka T*, Norioka K, Nakamura T, Mochizuki Y. Effects of Mitogens and Co-mitogens on the Formation of Small-Cell Colonies in Primary Cultures of Rat Hepatocytes. J Cell Physiol, 157(3), 461-468 (1993)
  55. Otani N, Tsukamoto T*, Saiki I, Yoneda J, Mitaka T, Kumamoto Y. In vitro invasive potential and type IV collagenolytic activity of human renal cell carcinoma cells derived from the primary and metastatic lesion. J Urology, 149(5), 1182-1185 (1993)
  56. Mitaka T*, Norioka K, Sattler GL, Pitot HC, Mochizuki Y. Effect of Age on the Formation of Small-Cell Colonies in Cultures of Primary Rat Hepatocytes. Cancer Res, 53(13), 3145-3148 (1993)
  57. Mitaka T*, Norioka K, Mochizuki Y. Redifferentiation of Proliferated Rat Hepatocytes Cultured in L-15 Medium Supplemented with EGF and DMSO. In Vitro Cell Dev Biol, 29A(9), 714-722 (1993)
  58. Norioka K*, Mitaka T, Mochizuki Y. Inhibition of tumor-induced angiogenesis by ribonuclease inhibitor. Tumor Res, 27, 15-23 (1992)
  59. Mitaka T*, Sattler GL, Pitot HC, Mochizuki Y. Characteristics of Small Cell Colonies Developing in Primary Cultures of Adult Rat Hepatocytes. Virchows Archiv B Cell Pathol, 62(5), 329-335 (1992).
  60. Mitaka T*, Mikami M, Sattler GL, Pitot HC, Mochizuki Y. Small Cell Colonies Appear in the Primary Culture of Adult Rat Hepatocytes in the Presence of Nicotinamide and Epidermal Growth Factor. Hepatology, 16(2), 440-447 (1992).
  61. Mitaka T, Sattler GL, Pitot HC*. The Bicarbonate Ion is Essential for Efficient DNA Synthesis by Primary Cultured Rat Hepatocytes. In Vitro Cell Dev Biol, 27A(7), 549-556 (1991).
  62. Xu Y-J, Sattler GL, Mitaka T, Zhang J-S, Pitot HC*. γ-Glutamyltranspeptidase-Positive (GGT+) Hepatocytes From Carcinogen-Treated Rats Isolated by Magnetic Beads. In Vitro Cell Dev Biol, 27A(7), 515-517 (1991)
  63. Mitaka T, Sattler GL, Pitot HC*. Amino Acid-Rich Medium (Leibovitz L-15) Enhances and Prolongs Proliferation of Primary Cultured Rat Hepatocytes in the Absence of Serum. J Cell Physiol, 147, 495-504 (1991).
  64. Mitaka T, Sattler CA, Sattler GL, Sargent LM, Pitot HC*. Multiple Cell Cycles Occur in Rat Hepatocytes Cultured in the Presence of Nicotinamide and Epidermal Growth Factor. Hepatology, 13, 21-30 (1991).
  65. Homma H*, Yokoi T, Mitaka T, Niitsu Y, Mochizuki Y. Modifying effects of clofibrate on the phenotype of glutathione S-transferase isoenzymes (YaYa, YbYb, YcYc, YkYk, and YpYp) during chemical carcinogenesis in rat livers. Tumor Res, 25, 7-19 (1990).
  66. Mitaka T*, Furukawa K, Tsukada H. Effects of cholesteryl hemisuccinate on phalloidin sensitivity of normal and preneoplastic rat hepatocytes. Tumor Res, 23, 59-64 (1988).
  67. Mitaka T*, Gotoh M, Tsukada H. Susceptibillity of rat preneoplastic hepatocytes to liver-tumor promoters: effects of phenobarbital and ethyl-α-p-chlorophenoxyisobutyrate on phalloidin sensitivity. Tumor Res, 23, 33-40 (1988).
  68. Mitaka T*, Tsukada H. Decreased Sensitivity to Phalloidin of Normal-looking Rat Hepatocytes after Short-term 2-Acetylaminofluorene Feeding. Jpn J Cancer Res, 79(3), 329-334 (1988).
  69. Mochizuki Y*, Furukawa K, Mitaka T, Yokoi T, Kodama T. Polygonal Networks, “Geodomes’, of Adult Rat Hepatocytes in Primary Culture. Cell Biol Internal Reports, 12(1), 1-7 (1988).
  70. Mitaka T*, Tsukada H. Decreased Sensitivity to Phalloidin of Aged F344/DuCrj Rat Hepatocytes. Jpn J Cancer Res, 78(11), 1193-1197 (1987).
  71. Mitaka T*, Tsukada H. Sexual difference in the Histochemical Characteristics of “Altered Cell Foci” in the Liver of Aged Fischer 344 Rats. Jpn J Cancer Res, 78(8), 785-790 (1987).
  72. 塚田英之、三高俊広.　肝癌のプロモーター.　肝胆膵、 15(5):863-868 (1987)．
  73. Tsukada H*, Sawada N, Mitaka T, Gotoh M. Effects of liver-tumor promoters on phalloidin sensitivity of rat hepatocytes. Carcinogenesis, 7(2), 335-337 (1986)
  74. Mitaka T*. Phalloidin uptake by preneoplastic rat hepatocyte. Tumor Res, 20, 61-65 (1985)

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