Department of Tissue Development and Regeneration,
Institute of Regenerative Medicine Sapporo Medical University School of Medicine

Grants(Before)

2002-2019

• Periods
• Foundations
  (Project Number)
• Principle
  Investigator
  (Co-investigator)
• Research Project

• 2017-2019
• Grant-in-Aid for
  Scientific Research (C)
  (17K08765)
• Ichinohe N
• Analysis of immunoregulation and mechanism of liver regeneration in cell transplantation

• 2017-2019
• Grant-in-Aid for
  Scientific Research (C)
  (17K10672)
• Mizuguchi T
  (Tanimizu N,
  Ichinohe N,
  Mitaka T)
• Translational research for clinical apply using liver stem cells from cell banking

• 2017-2018
• Grant-in-Aid for
  Scientific Research on
  innovative areas
  (17H05653)
• Tanimizu N
• Effects of aging on the lineage plasticity of hepatocytes

• 2017-2018
• Challenging Research
  (Exploratory) (17K19703)
• Mitaka T
• In vitro reconstruction of hepatic tissue

• 2016-2018
• Grant-in-Aid for
  Scientific Research (B)
  (16H03173)
• Sudo R
  (Mitaka T)
• Tissue engineering for vascularization on flow regulation

• 2016-2018
• Grant-in-Aid for
  Scientific Research (C)
  (16K08716)
• Tanimizu N
• The lineage plasticity of mature hepatocytes during liver injury and regeneration

• 2014-2016
• Grant-in-Aid for
  Scientific Research (C)
  (26461921)
• Mizuguchi T
  (Tanimizu N,
  Ichinohe N,
  Mitaka T)
• Translational research of the regenerative treatment of using human hepatic stem cells which were frozen by super-freezing program

• 2014-2015
• Grant-in-Aid for
  Challenging Research
  (Exploratory)
  (26670584)
• Mitaka T
• Research for the establishment of human hepatocytic progenitor cells

• 2014-2016
• Grant-in-Aid for
  Scientific Research (C)
  (26460474)
• Ichinohe N
• Hepatic stem cells transplantation activates the growth of intrinsic hepatic progenitor cells in recipient rat livers

• 2013-2015
• Grant-in-Aid for
  Scientific Research (B)
  (25282135)
• Sudo R
  (Mitaka T)
• Development of tissue engineering for vascularization based on regulation of interstitial flow

• 2013-2015
• Grant-in-Aid for
  Scientific Research (C)
  (25460271)
• Tanimizu N
• Role of liver stem/progenitor cells in development and regeneration

• 2013-2015
• Grant-in-Aid for
  Scientific Research (B)
  (25293289)
• Hirata K
  (Mitaka T,
  Tanimizu N)
• Fundamental researches for the application of human small hepatocytes in clinical treatment

• 2012-2014
• Grant-in-Aid for
  Scientific Research (B)
  (24390304)
• Mitaka T
• Establishment of cell transplantation therapy for hepatic failure by hepatic stem/progenitor cells and/or hepatic organoids

• 2012-2013
• Grant-in-Aid for
  Scientifi(C)
  Research on Innovative Areas
  (24112519)
• Tanimizu N
• 胆管をモデルとした、管腔構造の発達とチューブ構造形成を制御するメカニズムの解明 (Japanese)

• 2012-2013
• Grant-in-Aid for
  Young Scientists (B)
• Ichinohe N
• Tissue stem cells transplantation activates the growth of hepatic progenitor cells in recipient rat livers

• 2012-2013
• Grant-in-Aid for
  Challenging Exploratory Research
  (24659591)
• Mitaka T
• Development of the liver lobule-type culture device

• 2011-2013
• Grant-in-Aid for
  Scientific Research (C)
  (23501270)
• Kikkawa Y
  (Mitaka T)
• Roles of Lutheran in tumor cell adhesion and migration

• 2011-2013
• Grant-in-Aid for
  Scientific Research (C)
  (23591993)
• Mizuguchi T
  (Mitaka T)
• A clinical and basic research for developing human small hepatocyte bank using super-cooling program and generating mass hybrid mouse

• 2010-2011
• Grant-in-Aid for
  Young Scientists (B)
  (22790386)
• Tanimizu N
• Molecular mechanisms regulating epithelial morphogenesis during the development of bile ducts

• 2010-2011
• Grant-in-Aid for
  Young Scientists (B)
• Ichinohe N
• Analysis in activation of hepatic stem/progenitor cells and development of application to hepatic tissue engineering

• 2009-2011
• Grant-in-Aid for
  Scientific Research (B)
  (21390365)
• Mitaka T
• Basic research for the production of human hepatocytes and the transplantation of hepatic tissues

• 2008-2010
• Grant-in-Aid for
  Scientific Research (C)
  （20591615）
• Mizuguchi T
  (Mitaka T)
• Development of hybrid mouse with humanized liver using superfreezing preserved human small hepatocytes

• 2008-2010
• Grant-in-Aid for
  Scientific Research (C)
  (20500412)
• Kikkawa Y
  (Mitaka T)
• Primary culture of hepatocytes on synthetic peptides mimicking the functions of laminin-111

• 2007-2009
• Grant-in-Aid for
  Scientific Research (B) (19390353)
• Hirata K
  (Mitaka T)
• Basic research objected to establish the highly qualified assessment of hepatic reserve function by utilizing new molecular marker localized in liver

• 2007-2008
• Grant-in-Aid for
  Scientific Research (C)
  (19579001)
• Tanimizu N
• Analysis of molecular mechanisms governing tubular morphogenesis of hepatic bile ducts using three dimensional culture

• 2007-2008
• Grant-in-Aid for
  Scientific Research (C)
  (19599021)
• Ichinohe N
• Hepatic organoid formation by coculture with small hepatocytes and bone marrow stromal cells

• 2005-2007
• Grant-in-Aid for
  Scientific Research (B)
  (17390353)
• Mitaka T
• Research for the formation of hepatic organoids by using human hepatic progenitor cells and the model of artificial liver device incorporated with human hepatic organoids

• 2005-2007
• Grant-in-Aid for
  Scientific Research (C)
  (17590307)
• Kikkawa Y
  (Mitaka T)
• Role of laminin alpha5 and its receptors in fibrotic liver and hepatocellular carcinoma

• 2005-2007
• Ministry of Health,
  Labour and Welfare,
  Japan, Health and Labour Sciences Research Grants, Research on Advanced
  Medical Technology
  (200708008B)
• Mitaka T
• 肝ステム細胞を用いた毒性発現の評価解析方法の確立 （Japanese）

• 2003-2004
• Grant-in-Aid for
  Challenging Exploratory Research
  (1565099)
• Tanishita K
  (Mitaka T)
• 再生毛細胆管の収縮を生み出す小型肝細胞収縮の同期機構のバイオメカニクス (Japanese)

• 2003-2005
• Grant-in-Aid for
  Scientific Research (B)
  (15390403)
• Hirata K
  (Mitaka T)
• Research of the mechanism of non-obstructive cholestasis in severe infection and of the treatment for hepatic insufficiency

• 2002
• Grant-in-Aid for
  Scientific Research (C)
  (14607002)
• Sugiyama T
  (Mitaka T)
• 肝・胆・膵系ステムセル・バイオロジーと臓器再生医療への展開 (Japanese)

• 2002-2003
• Grant-in-Aid for
  Scientific Research (B)
  (14270353)
• Ikai I
  (Mitaka T)
• Isolation and characterization of human hepatic stem/progenitor cells and reconstruction of liver tissue

• 2002-2004
• Grant-in-Aid for
  Scientific Research (B)
  (14370353)
• Mitaka T
• Identification of specific surface proteins in small hepatocytes and reconstruction of hepatic organoids ex vivo