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Research Activity

Reviews

  • Okita K, Mizuguchi T, Ota S, Ishi M, Nishidate T, Ueki T, Meguro M, Kimura Y, Tanimizu N, Ichinohe N, Torigoe T, Kojima T, Mitaka T, Sato N, Sawada N, Hirata K. Pancreatic regeneration: basic research and gene regulation. Surg Today, 2016 Jun; 46(6): 633-640. doi: 10.1007/s00595-015-1215-2.

Original Articles

*Correspondence

  1. Tanimizu N*, Ichinohe N, Suzuki H, Mitaka T. Prolonged oxidative stress and delayed tissue repair exacerbate acetaminophen induced liver injury in aged mice. Aging, in press
  2. Kino J*, Ichinohe N*, Ishii M, Suzuki H, Mizuguchi T, Tanimizu N, Mitaka T. Self-renewal capability of hepatocytic parental progenitor cells derived from adult rat liver is maintained long term when cultured on laminin 111 in serum-free medium. Hepatology communication. (2019). DOI 10.1002/hep4.1442
  3. Kino J, Ichinohe N, Ishii M, Mitaka T*. Isolation and expansion of rat hepatocytic progenitor cells. Methods Mol Biol, 1905: 29-41 (2019) doi: 10.1007/978-1-4939-8961-4_4
  4. Tanimizu N*, Ichinohe N, Mitaka T. Intrahepatic bile ducts guide formation of the hepatic nervous system in developing mouse liver. Development, Apr 25; 145(9). pii: dev159095 (2018) doi: 10.1242/dev.159095.
  5. Ishii M, Kino J, Ichinohe N, Tanimizu N, Ninomiya T, Suzuki H, Mizuguchi T, Hirata K, Mitaka T*. Hepatocytic parental progenitor cells of rat small hepatocytes maintain a self-renewal capability after long-term culture. Sci Rep, Apr 11; 7: 46177 (2017) DOI: 10.1038/srep46177
  6. Tanimizu N*, Ichinohe N, Yamamoto M, Akiyama H, Nishikawa Y, Mitaka T. Progressive induction of liver progenitor cells in chronically injured liver. Sci Rep, Jan 4; 7: 39990 (2017) doi: 10.1038/srep39990
  7. Ichinohe N*, Ishii M, Tanimizu N, Kon J, Mizuguchi T, Hirata K, Mitaka T*. Transplantation of galactosamine-induced hepatic Thy1-positive cells activates the growth of intrinsic hepatic progenitor cells in retrorsine-treated rat livers. Stem Cells, 35(4): 920-931 (2017)
  8. Tanimizu N*, Ichinohe N, Ishii M, Kino J, Mizuguchi T, Hirata K, Mitaka T. Liver progenitors isolated from adult healthy mouse liver efficiently differentiate to functional hepatocytes in vitro and repopulate liver tissue. Stem Cells, 34(12):2889-2901 (2016)
  9. Tanimizu N*, Kaneko K, Itoh T, Ichinohe N, Ishii M, Mizuguchi T, Hirata K, Miyajima A, Mitaka T. Intrahepatic bile ducts are developed through formation of homogeneous continuous luminal network and its dynamic rearrangement. Hepatology, 64(1):175-188 (2016)
  10. Okita K, Mizuguchi T, Ota S, Ishi M, Nishidate T, Ueki T, Meguro M, Kimura Y, Tanimizu N, Ichinohe N, Torigoe T, Kojima T, Mitaka T, Sato N, Sawada N, Hirata K (Review). Pancreatic regeneration: basic research and gene regulation. Surg Today, 46(6):633-640 (2016)

  11. Tanimizu N*, Kobayashi S, Ichinohe N, Mitaka T. Downregulation of miR122 by grainyhead like-2 restricts the hepatocytic differentiation potential of adult liver progenitor cells. Development, 141(23): 4448-4456 (2014)
  12. Tanimizu N, Nishikawa Y, Ichinohe N, Akiyama H, Mitaka T. Sry HMG box protein 9-positive (Sox9+) epithelial cell adhesion molecule-negative (EpCAM-) biphenotypic cells derived from hepatocytes are involved in mouse liver regeneration. J Biol Chem, Mar 14;289(11):7589-7598 (2014)
  13. Nakamura Y, Mizuguchi T, Tanimizu N, Ooe H, Ichinohe N, Hirata K, Mitaka T. Preoperative hepatocyte transplantation prevents cirrhotic rats from receiving the fatal damage by a liver resection. Cell Transplant, 23(10):1243-1254 (2014)
  14. Tanimizu N*, Nakamura Y, Ichinohe N, Mizuguchi T, Hirata K, Mitaka T. Hepatic biliary epithelial cells acquire epithelial integrity but lose plasticity to differentiate into hepatocytes in vitro during development. J Cell Sci, 126(Ppt22): 5239-5246 (2013)
  15. Ichinohe N*, Tanimizu N, Ooe H, Nakamura Y, Mizuguchi T, Hirata K, Kon J, Mitaka T*. Differentiation capacity of hepatic stem/progenitor cells isolated from d-galactosamine-treated rat livers. Hepatology, 57(3): 1192-1202 (2013)
  16. Ichinohe N, Kon J, Mitaka T*. Isolation of hepatic progenitor cells from the galactosamine-treated rat liver. Methods Mol Biol, 826:49-58 (2012)
  17. Takamoto T, Ichinohe N, Tabata Y*. Proliferation of Rat Mesenchymal Stem Cells in Collagen Sponges Reinforced with Poly(Ethylene Terephthalate) Fibers by Stirring Culture Method. J Biomater Sci Polym Ed, 23(13):1741-1753 (2012)　
  18. Ooe H, Chen Q, Kon J, Sasaki K, Miyoshi H, Ichinohe N, Tanimizu N, Mitaka T. Proliferation of rat small hepatocytes requires follistatin expression. J Cell Physiol. Jun; 227(6): 2363-2370 (2012)
  19. Ichinohe N, Kon J, Sasaki K, Nakamura Y, Ooe H, Tanimizu N, Mitaka T. Growth ability and repopulation efficiency of transplanted hepatic stem cells, progenitor cells, and mature hepatocytes in retrorsine-treated rat livers. Cell Transplant 21(1): 11-22 (2012)
  20. Ichinohe N, Nakano T, Mitaka T, Umakoshi Y, Tabata Y. Proliferation and osteogenic differentiation of rat bone-marrow stromal cells on bio-apatite with different crystalline facets. J Biomed Mater Res, Part A, 93A(2): 646-655 (2010)
  21. Kon J, Ichinohe N, Ooe H, Chen Q, Sasaki K, Mitaka T. Thy1-positive cells have bipotential ability to differentiate into mature hepatocytes and biliary epithelial cells in galactosamine-induced rat liver regeneration. Am J Pathol, 175(6): 2362-2371 (2009)
  22. Ichinohe N, Kuboki Y, Tabata Y. Bone regeneration using titanium nonwoven fabrics combined with FGF-2 release from gelatin hydrogel microspheres in rabbit skull defects. Tissue Engineer Part A, 14(10): 1663-1671 (2008) 　
  23. Ichinohe N, Takamoto T, Tabata Y. Proliferation, osteogenic differentiation, and distribution of rat bone marrow stromal cells in nonwoven fabrics by different culture methods. Tissue Engineer Part A. 14(1): 107-116 (2008) 　　　　　　

Norihisa Ichinohe, D.D.S., Ph.D.